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J Neurol. 1990 Apr;237(2):113-6.

Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. A report of three cases.

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Neurologische Universit├Ątsklinik und Poliklinik, W├╝rzburg, Federal Republic of Germany.


Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.

[Indexed for MEDLINE]

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