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Nat Rev Genet. 2013 May;14(5):360-6. doi: 10.1038/nrg3456. Epub 2013 Apr 4.

Functional and evolutionary implications of gene orthology.

Author information

1
Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain. tgabaldon@crg.es

Abstract

Orthologues and paralogues are types of homologous genes that are related by speciation or duplication, respectively. Orthologous genes are generally assumed to retain equivalent functions in different organisms and to share other key properties. Several recent comparative genomic studies have focused on testing these expectations. Here we discuss the complexity of the evolution of gene-phenotype relationships and assess the validity of the key implications of orthology and paralogy relationships as general statistical trends and guiding principles.

PMID:
23552219
PMCID:
PMC5877793
DOI:
10.1038/nrg3456
[Indexed for MEDLINE]
Free PMC Article

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