Format

Send to

Choose Destination
Retrovirology. 2013 Apr 3;10:36. doi: 10.1186/1742-4690-10-36.

Limited cross-border infections in patients newly diagnosed with HIV in Europe.

Collaborators (237)

Puchhammer-Stockl E, Sarcletti M, Schmied B, Geit M, Balluch G, Vandamme A-, Vercauteren J, Derdelinckx I, Sasse A, Bogaert M, Ceunen H, De Roo A, De Wit S, Echahidi F, Fransen K, Goffard J-, Goubau P, Goudeseune E, Yombi J-, Lacor P, Liesnard C, Moutschen M, Pierard D, Rens R, Schrooten Y, Vaira D, Vandekerckhove LP, Van den Heuvel A, Van Der Gucht B, Van Ranst M, Van Wijngaerden E, Vandercam B, Vekemans M, Verhofstede C, Clumeck N, Van Laethem K, Kostrikis L, Demetriades I, Kousiappa I, Demetriou V, Hezka J, Bruckova M, Linka M, Machala L, Nielsen C, Jørgensen L, Gerstoft J, Mathiesen L, Pedersen C, Nielsen H, Laursen A, Kvinesdal B, Salminen M, Ristola M, Liitsola K, Suni J, Sutinen J, Korn K, Kücherer C, Berg T, Braun P, Poggensee G, Däumer M, Eberle J, Hamouda O, Heiken H, Kaiser R, Knechten H, Müller H, Neifer S, Schmidt B, Walter H, Gunsenheimer-Bartmeyer B, Harrer T, Paraskevis D, Hatzakis A, Magiorkinis E, Hatzitheodorou E, Haida C, Zavitsanou A, Magiorkinis G, Lazanas M, Chini M, Magafas N, Tsogas N, Paparizos V, Kourkounti S, Antoniadou A, Papadopoulos A, Panagopoulos P, Poulakou G, Sakka V, Chryssos G, Drimis S, Gargalianos P, Lelekis M, Chilomenos G, Psichogiou M, Daikos G, Panos G, Haratsis G, Kordossis T, Kontos A, Koratzanis G, Theodoridou M, Mostrou G, Spoulou V, Coughlan S, De Gascun C, Byrne C, Duffy M, Bergin C, Reidy D, Farrell G, Lambert J, O'Connor E, Rochford A, Low J, Coakely P, O'Dea S, Hall W, Grossman Z, Levi I, Chemtob D, Balotta C, Franzetti M, Lai A, Binda F, Tramuto F, Ciccozzi M, Mussini C, Angarano G, Rezza G, Schmit J, Struck D, Hemmer R, Arendt V, Staub T, Schneider F, Roman F, Wensing A, Boucher C, van de Vijver D, van Kessel A, van Bentum P, Brinkman K, op de Coul E, van der Ende M, Hoepelman I, van Kasteren M, Juttmann J, Kuipers M, Langebeek N, Richter C, Santegoets R, Schrijnders-Gudde L, Schuurman R, van de Ven B, Åsjö B, Ormaasen V, Aavitsland P, Horban A, Stanczak J, Stanczak G, Firlag-Burkacka E, Wiercinska-Drapalo A, Jablonowska E, Małolepsza E, Leszczyszyn-Pynka M, Szata W, Camacho R, Palma C, Borges F, Paixão T, Duque V, Araújo F, Stanojevic M, Jevtovic Dj, Salemovic D, Stanekova D, Habekova M, Mokras M, Truska P, Poljak M, Lunar M, Babic D, Tomazic J, Vidmar L, Vovko T, Karner P, Clotet B, Domingo P, Galindo M, Miralles C, del Pozo MA, Ribera E, Iribarren J, Ruiz L, de la Torre J, Vidal F, Garcia F, Paredes R, Albert J, Heidarian A, Aperia-Peipke K, Axelsson M, Mild M, Karlsson A, Sönnerborg A, Thalme A, Navér L, Bratt G, Karlsson A, Blaxhult A, Gisslén M, Svennerholm B, Bergbrant I, Björkman P, Säll C, Mellgren Å, Lindholm A, Kuylenstierna N, Montelius R, Azimi F, Johansson B, Carlsson M, Johansson E, Ljungberg B, Ekvall H, Strand A, Mäkitalo S, Öberg S, Holmblad P, Höfer M, Holmberg H, Josefson P, Ryding U.

Author information

1
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

BACKGROUND:

International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe.

RESULTS:

Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged between 2 and 28. A number of 987 patients (74.2%) were part of a cluster that consisted only of patients originating from the same country. In addition, 135 patients (10.2%) were in a cluster including only individuals from neighboring countries. Finally, 208 patients (15.6%) clustered with individuals from countries without a common border. Clustering with patients from the same country was less prevalent in patients being infected with B subtype (P-value <0.0001), in men who have sex with men (P-value <0.0001), and in recently infected patients (P-value =0.045).

CONCLUSIONS:

Our findings indicate that the transmission of HIV-1 in Europe is predominantly occurring between patients from the same country. This could have implications for HIV-1 transmission prevention programmes. Because infections through travelling between countries is not frequently observed it is important to have good surveillance of the national HIV-1 epidemics.

PMID:
23551870
PMCID:
PMC3626648
DOI:
10.1186/1742-4690-10-36
[Indexed for MEDLINE]
Free PMC Article

Publication type, MeSH terms, Substance, Secondary source ID

Publication type

MeSH terms

Substance

Secondary source ID

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center