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Pediatr Transplant. 2013 Jun;17(4):343-7. doi: 10.1111/petr.12077. Epub 2013 Apr 3.

Results of single-center screening for chronic hepatitis E in children after liver transplantation and report on successful treatment with ribavirin.

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Pediatric Gastroenterology and Hepatology, Children's Hospital, Hannover Medical School, Hannover, Germany.


RNA screening for HEV in 22 liver-transplanted children with chronic graft hepatitis out of a cohort of 267 liver-transplanted children detected a single patient with chronic HEV infection. Although this patient remained viremic for 33 months, anti-HEV-IgG was not detectable with MP assay but with Wantai assay. We present the first case of successful ribavirin therapy in an immunosuppressed child with chronic HEV infection. In conclusion, chronic HEV infection in immunosuppressed children may not be detectable employing serological assays. Therefore, the most reliably screening method is screening for HEV-RNA. Chronic HEV infection in children can successfully be treated with ribavirin.

[Indexed for MEDLINE]

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