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Acta Paediatr. 2013 Jul;102(7):718-26. doi: 10.1111/apa.12248. Epub 2013 Apr 22.

Long-term growth of children with autoantibody-mediated congenital heart block.

Author information

1
Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Abstract

AIM:

To analyse growth of children with and without congenital heart block (CHB) born to anti-Ro/SSA positive mothers from birth to 18 years of age, using a population-based cohort of Swedish CHB patients.

METHODS:

Medical records for siblings with (n = 72) and without (n = 60) CHB born 1973-2009 to anti-Ro/SSA positive mothers were retrieved from child healthcare centres and school health services and used to extract data on growth from birth to 18 years.

RESULTS:

Compared with reference standards, children with CHB were retarded in weight by 0.75-1.0 SD from birth to 2-3 years of age. Thereafter, the CHB children started to catch up, reaching the reference standards at 9-11 years of age. Pacemaker treatment was not correlated with the catch-up in growth. Individuals with CHB were retarded in both weight and height from birth to 9-11 years of age when compared to siblings without CHB, who did not demonstrate restriction in these measurements.

CONCLUSION:

Presence of CHB is a more important predictor of growth restriction than maternal rheumatic disease and foetal anti-Ro/SSA exposure. The restriction persists for several years after birth, despite pacemaker treatment, which highlights the importance of follow-up of children with CHB regarding nutrition and growth.

PMID:
23551183
DOI:
10.1111/apa.12248
[Indexed for MEDLINE]

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