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Ann N Y Acad Sci. 2013 Mar;1280:24-6. doi: 10.1111/nyas.12027.

Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity.

Author information

1
Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, United Kingdom. Klaus.okkenhaug@babraham.ac.uk

Abstract

Mammalian cells can express up to four different class I phosphatidylinositide 3-kinase (PI3K) isoforms, each of which is engaged by tyrosine kinases or G protein-coupled receptors (GPCRs) to generate the second messenger signaling molecule PtdIns(3,4,5)P₃ (PIP₃). The p110α and p110β isoforms are relatively widely expressed, whereas p110γ and p110δ are more highly expressed in cells of the immune system than in other cell types. Nevertheless, each of the four class I PI3Ks have been shown to participate in the orchestration of the signaling events that lead to immune cell development and control of gene expression, skewing toward individual cell lineage subsets and proliferation.

PMID:
23551098
PMCID:
PMC4523620
DOI:
10.1111/nyas.12027
[Indexed for MEDLINE]
Free PMC Article

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