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Gut Microbes. 2013 May-Jun;4(3):253-8. doi: 10.4161/gmic.24220. Epub 2013 Apr 2.

The complex interplay between inflammation, the microbiota and colorectal cancer.

Author information

1
Department of Medicine, Pharmacology and Immunology-Microbiology, University of North Carolina, Chapel Hill, NC, USA.

Abstract

The microbiome has captured the attention of scientists from multiple research fields including ecology, immunology, microbiology and cancer biology. The microbial community living in the gastrointestinal tract is the most abundant and diverse niche of the human body and it is not surprising that microbiome research has predominantly focused upon this organ system. In this addendum, we summarize the latest developments in microbiome research on inflammatory bowel diseases and colorectal cancer. In addition, we highlight our recent findings that chronic intestinal inflammation modulates microbial community composition and the development of colorectal cancer. Our findings redefine the paradigm of inflammation-associated cancer by illuminating the key role of bacteria in development of colorectal cancer.

KEYWORDS:

Escherichia coli; bacterial toxin; colibactin; colon cancer; inflammation; microbiome

PMID:
23549517
PMCID:
PMC3669172
DOI:
10.4161/gmic.24220
[Indexed for MEDLINE]
Free PMC Article

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