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Nat Rev Microbiol. 2013 May;11(5):349-55. doi: 10.1038/nrmicro3007. Epub 2013 Apr 3.

Genome architecture and global gene regulation in bacteria: making progress towards a unified model?

Author information

1
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland. cjdorman@tcd.ie

Abstract

Data obtained with advanced imaging techniques, chromosome conformation capture methods, bioinformatics and molecular genetics, together with insights from polymer physics and mechanobiology, are helping to refine our understanding of the spatiotemporal organization of the bacterial nucleoid and its gene expression programmes. Here, I discuss the proposal that, in addition to DNA topology and nucleoid-associated proteins, gene regulation is an important organizing principle of nucleoid architecture.

PMID:
23549066
DOI:
10.1038/nrmicro3007
[Indexed for MEDLINE]

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