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Nat Cell Biol. 2013 Apr;15(4):348-50. doi: 10.1038/ncb2723.

Polycomb complex recruitment in pluripotent stem cells.

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1
Center of Regenerative Medicine in Barcelona, Aiguader 88, E-08003 Barcelona, Spain.

Abstract

The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

PMID:
23548929
DOI:
10.1038/ncb2723
[Indexed for MEDLINE]
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