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Leuk Lymphoma. 2013 Dec;54(12):2720-7. doi: 10.3109/10428194.2013.790542. Epub 2013 May 15.

Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes.

Author information

1
Department of Pathology, Immunology, and Microbiology.

Abstract

Myelodysplastic syndromes (MDS) are a group of hematopoietic malignancies characterized by ineffective hematopoiesis. Recently, we identified MDS-associated microRNAs (miRNAs) that are down-regulated in MDS. This study examines possible explanations for that observed down-regulation of miRNA expression in MDS. Since genomic losses are insufficient to explain the down-regulation of all our MDS-associated miRNAs, we explored other avenues. We demonstrate that these miRNAs are predominantly intragenic, and that, in many cases, they and their host genes are expressed in a similar pattern during myeloid maturation, suggesting their co-regulation. This co-regulation is further supported by the down-regulation of several of the host genes in MDS and increased methylation of the shared promoters of several miRNAs and their respective host genes. These studies identify a role of hypermethylation of miRNA promoters in the down-regulation of MDS-associated miRNAs, unifying research on miRNAs in MDS and epigenetic regulation in MDS into a common pathway.

PMID:
23547841
PMCID:
PMC4120331
DOI:
10.3109/10428194.2013.790542
[Indexed for MEDLINE]
Free PMC Article

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