Format

Send to

Choose Destination
Cereb Cortex. 2014 Aug;24(8):2229-36. doi: 10.1093/cercor/bht084. Epub 2013 Mar 31.

Working memory coding of analog stimulus properties in the human prefrontal cortex.

Author information

1
Dahlem Institute for Neuroimaging of Emotion, Freie Universität Berlin, Berlin 14195, Germany, bernhard.spitzer@fu-berlin.de.
2
Bernstein Center for Computational Neuroscience, Berlin 10115, Germany and.
3
Bernstein Center for Computational Neuroscience, Berlin 10115, Germany and Center for Adaptive Rationality (ARC), Max Planck Institute for Human Development, Berlin 14195, Germany.
4
Dahlem Institute for Neuroimaging of Emotion, Freie Universität Berlin, Berlin 14195, Germany, Center for Adaptive Rationality (ARC), Max Planck Institute for Human Development, Berlin 14195, Germany.

Abstract

Building on evidence for working memory (WM) coding of vibrotactile frequency information in monkey prefrontal cortex, recent electroencephalography studies found frequency processing in human WM to be reflected by quantitative modulations of prefrontal upper beta activity (20-30 Hz) as a function of the to-be-maintained stimulus attribute. This kind of stimulus-dependent activity has been observed across different sensory modalities, suggesting a generalized role of prefrontal beta during abstract WM processing of quantitative magnitude information. However, until now the available empirical evidence for such quantitative WM representation remains critically limited to the retention of periodic stimulus frequencies. In the present experiment, we used retrospective cueing to examine the quantitative WM processing of stationary (intensity) and temporal (duration) attributes of a previously presented tactile stimulus. We found parametric modulations of prefrontal beta activity during cued WM processing of each type of quantitative information, in a very similar manner as had before been observed only for periodic frequency information. In particular, delayed prefrontal beta modulations systematically reflected the magnitude of the retrospectively selected stimulus attribute and were functionally linked to successful behavioral task performance. Together, these findings converge on a generalized role of stimulus-dependent prefrontal beta-band oscillations during abstract scaling of analog quantity information in human WM.

KEYWORDS:

EEG; oscillations; somatosensory; stimulus coding; working memory

PMID:
23547134
DOI:
10.1093/cercor/bht084
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center