Send to

Choose Destination
See comment in PubMed Commons below
Oncogenesis. 2013 Apr 1;2:e41. doi: 10.1038/oncsis.2013.1.

Three different brain tumours evolving from a common origin.

Author information

Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, London, UK.


Despite an improved understanding of the molecular aberrations that occur in glioblastoma, the use of molecularly targeted therapies have so far been disappointing. We present a patient with three different brain tumours: astrocytoma, glioblastoma and gliosarcoma. Genetic analysis showed that the three different brain tumours were derived from a common origin but had each developed unique genetic aberrations. Included in these, the glioblastoma had PDGFRA amplification, whereas the gliosarcoma had MYC amplification. We propose that genetic heterogeneity contributes to treatment failure and requires comprehensive assessment in the era of personalised medicine.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center