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Dev Comp Immunol. 2014 Jan;42(1):42-6. doi: 10.1016/j.dci.2013.03.014. Epub 2013 Mar 30.

The Drosophila clotting system and its messages for mammals.

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Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden. Electronic address:


Drosophila has been increasingly used as a model to study hemolymph clotting. Proteomics and bioinformatics identified candidate clotting-factors, several of which were tested using genetics. Mutants and lines with reduced expression of clotting-factors show subtle effects after wounding, indicating that sealing wounds may rely on redundant mechanisms. More striking effects are observed after infection, in particular when a natural infection model involving entomopathogenic nematodes is used. When translated into mammalian models these results reveal that mammalian blood clots serve a similar immune function, thus providing a new example of the usefulness of studying invertebrate models.


APMAP; Hml; Ig; Innate immunity; Insect immunity; Phenoloxidase; Transglutaminase; adipocyte membrane associated protein; hemolectin; immunoglobulin

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