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Cytokine Growth Factor Rev. 2013 Jun;24(3):241-8. doi: 10.1016/j.cytogfr.2013.03.005. Epub 2013 Mar 30.

Suppression of cytokine signaling: the SOCS perspective.

Author information

1
Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Abstract

The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian contribution to this field has been substantial, with the initial discovery of SOCS1 by Hilton, Starr and colleagues (discovered concurrently by two other groups) and the following work, providing a new perspective on the regulation of JAK/STAT signaling. In this review, we reflect on the critical discoveries that have lead to our current understanding of how SOCS proteins function and discuss what we see as important questions for future research.

KEYWORDS:

Cytokine; JAK; Receptor; SOCS; SOCS box

PMID:
23545160
PMCID:
PMC3816980
DOI:
10.1016/j.cytogfr.2013.03.005
[Indexed for MEDLINE]
Free PMC Article

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