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Indian J Pharmacol. 2013 Jan-Feb;45(1):40-3. doi: 10.4103/0253-7613.106433.

Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats.

Author information

1
Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur, Odisha, India.

Abstract

OBJECTIVES:

The aim of the present study was to evaluate the anti-convulsant potential of aqueous and ethanol e xtract of Glycyrrhiza glabra (AEGG and EEGG) and its action on markers of oxidant stress in albino rats.

MATERIALS AND METHODS:

The aqueous and ethanol extract of Glycyrrhiza glabra was tested at three doses viz. 100, 200, and 400 mg/kg i.p. for its anti-convulsant activity using pentylenetetrazole (PTZ)-induced seizure in rat. The effect of EEGG (400 mg/kg, i.p.) on oxidative stress markers like malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) of rat brain tissue homogenate was tested.

RESULTS:

The onset of seizure was delayed (P < 0.01) by all the three doses of EEGG, but the duration of convulsion was reduced (P < 0.01) only in higher dose level (200 and 400 mg/ kg), whereas AEGG up to 400 mg/kg did not alter any of the parameters significantly. Biochemical analysis of rat brain tissue revealed that MDA was increased (P < 0.01), whereas SOD and CAT were decreased (P < 0.01) in PTZ-induced seizure rat, whereas pre-treatment with EEGG (400 mg/kg) decreased (P < 0.01) the MDA and increased (P < 0.01) both SOD and CAT, indicating attenuation of lipid peroxidation due to increase in antioxidant enzymes.

CONCLUSION:

The results demonstrated that EEGG poses anti-convulsant potential and ameliorates ROS induced neuronal damage in PTZ-induced seizure.

KEYWORDS:

Catalase; Glycyrrhiza glabra; malondialdehyde; pentylenetetrazole; seizures; superoxide dismutase

PMID:
23543836
PMCID:
PMC3608293
DOI:
10.4103/0253-7613.106433
[Indexed for MEDLINE]
Free PMC Article

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