Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 1990 Apr 2;512(2):343-6.

Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization.

Author information

  • 1Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Abstract

This experiment examined the effects of intracerebroventricular (i.c.v.) administration of a corticotropin-releasing factor (CRF) antagonist on the development of stress-induced sensitization of the behavioral response to amphetamine. Restraint stress was found to enhance both the locomotor response to a s.c. injection of saline and the intensity of stereotypy induced by a s.c. injection of 3.0 mg/kg D-amphetamine. Both of these effects of restraint stress were severely attenuated in rats that had been injected with the CRF antagonist prior to restraint stress. This result is compatible with the hypothesis that CRF is critically involved in initiating behavioral and physiological responses to aversive stimuli.

PMID:
2354366
DOI:
10.1016/0006-8993(90)90646-S
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center