Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2013 May;16(5):526-8. doi: 10.1038/nn.3372. Epub 2013 Mar 31.

Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.

Author information

1
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York, USA.

Abstract

Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.

PMID:
23542692
PMCID:
PMC3637869
DOI:
10.1038/nn.3372
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center