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J Trop Pediatr. 2013 Aug;59(4):309-13. doi: 10.1093/tropej/fmt017. Epub 2013 Mar 28.

Intrafamilial transmission of hepatitis C infection in Egyptian multitransfused thalassemia patients.

Author information

1
Clinical Pathology Department, Cairo University, Cairo, Egypt. f2said@yahoo.com

Abstract

OBJECTIVE:

Detecting the current prevalence of hepatitis C virus (HCV) among Egyptian multitransfused thalassemic patients and evaluating the risk of its transmission within their family members.

METHODS:

Multitransfused Egyptian thalassemia patients (n = 137) were tested for HCV infection. Household contacts of positive members were compared with household contacts of HCV-negative patients. Antibodies to HCV were detected by enzyme immunoassay. Antibody-positive cases were retested for viral load using reverse transcriptase polymerase chain reaction. HCV genotyping was performed on positive samples of the patients and the positive household contacts.

RESULTS:

In all, 34.4% of patients (n = 47) were positive for HCV antibodies and RNA. The study of 24 families of HCV-positive patients showed 14 affected family members (19.2%). In 27 families of HCV-negative patients, four family members were affected (4.9%). HCV genotyping of seven families was similar in both patients and their family members.

CONCLUSION:

Our results support the role of intrafamilial transmission in the spread of HCV.

KEYWORDS:

Egypt; hepatitis C; intrafamilial; multitransfused; thalassemia

PMID:
23542535
DOI:
10.1093/tropej/fmt017
[Indexed for MEDLINE]

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