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FEBS Lett. 2013 May 2;587(9):1299-303. doi: 10.1016/j.febslet.2013.03.024. Epub 2013 Mar 28.

Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.

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1
Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8505, Japan.

Abstract

The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show that knockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB-crystallin (αBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23 plays a protective role against UVC by accumulating αBC in the close vicinity of the ER.

PMID:
23542032
DOI:
10.1016/j.febslet.2013.03.024
[Indexed for MEDLINE]
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