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Diagn Microbiol Infect Dis. 2013 May;76(1):119-21. doi: 10.1016/j.diagmicrobio.2013.02.030. Epub 2013 Mar 27.

A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.

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Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan.


We investigated 5 metallo-β-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where blaIMP-34 is located on a transmissible plasmid.

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