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Infect Genet Evol. 2013 Jul;17:162-87. doi: 10.1016/j.meegid.2013.02.020. Epub 2013 Mar 26.

Connecting the study of wild influenza with the potential for pandemic disease.

Author information

1
Massachusetts Institute of Technology, Cambridge, MA, United States. jrun@mit.edu

Abstract

Continuing outbreaks of pathogenic (H5N1) and pandemic (SOIVH1N1) influenza have underscored the need to understand the origin, characteristics, and evolution of novel influenza A virus (IAV) variants that pose a threat to human health. In the last 4-5years, focus has been placed on the organization of large-scale surveillance programs to examine the phylogenetics of avian influenza virus (AIV) and host-virus relationships in domestic and wild animals. Here we review the current gaps in wild animal and environmental surveillance and the current understanding of genetic signatures in potentially pandemic strains.

PMID:
23541413
PMCID:
PMC3685205
DOI:
10.1016/j.meegid.2013.02.020
[Indexed for MEDLINE]
Free PMC Article
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