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ACS Nano. 2013 Apr 23;7(4):3036-44. doi: 10.1021/nn4006544. Epub 2013 Apr 10.

Biomimetic antigenic nanoparticles elicit controlled protective immune response to influenza.

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Department of Chemistry and Biochemistry, Center for Bio-Inspired Nanomaterials, Montana State University, Bozeman, Montana 59717, United States.


Here we present a biomimetic strategy toward nanoparticle design for controlled immune response through encapsulation of conserved internal influenza proteins on the interior of virus-like particles (VLPs) to direct CD8+ cytotoxic T cell protection. Programmed encapsulation and sequestration of the conserved nucleoprotein (NP) from influenza on the interior of a VLP, derived from the bacteriophage P22, results in a vaccine that provides multistrain protection against 100 times lethal doses of influenza in an NP specific CD8+ T cell-dependent manner. VLP assembly and encapsulation of the immunogenic NP cargo protein is the result of a genetically programmed self-assembly making this strategy amendable to the quick production of vaccines to rapidly emerging pathogens. Addition of adjuvants or targeting molecules were not required for eliciting the protective response.

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