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Clin Liver Dis. 2013 May;17(2):161-89. doi: 10.1016/j.cld.2012.12.001.

Nuclear receptors as drug targets in cholestatic liver diseases.

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1
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Abstract

Cholestatic liver diseases encompass a wide spectrum of disorders with different causes, resulting in impaired bile flow and accumulation of bile acids and other potentially hepatotoxic cholephils. The understanding of the molecular mechanisms of bile formation and cholestasis has recently improved significantly through new insights into nuclear receptor (patho)biology. Nuclear receptors are ligand-activated transcription factors, which act as central players in the regulation of genes responsible for elimination and detoxification of biliary constituents accumulating in cholestasis. They also control other pathophysiologic processes such as inflammation, fibrogenesis, and carcinogenesis involved in the pathogenesis and disease progression of cholestasis liver diseases.

PMID:
23540496
PMCID:
PMC3633080
DOI:
10.1016/j.cld.2012.12.001
[Indexed for MEDLINE]
Free PMC Article
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