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Springerplus. 2013 Dec;2(1):101. doi: 10.1186/2193-1801-2-101. Epub 2013 Mar 12.

Suspected acute exacerbation of idiopathic pulmonary fibrosis associated with interferon alpha therapy for hepatitis C: case report.

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Department of Respiratory Medicine, Mater Adult Hospital, South Brisbane, Qld 4101 Australia.


Interferon alpha (IFNα) has immune stimulatory actions implicated in its pulmonary toxicities. We describe deterioration of idiopathic pulmonary fibrosis (IPF) associated with IFNα treatment for chronic hepatitis C in a 58 year old woman culminating in a fatal suspected acute exacerbation of IPF (AE-IPF). Caution should be exercised in the use of IFNα in subjects with concomitant IPF given its known immunostimulatory effects and possible role in this suspected AE-IPF.


Acute exacerbation of idiopathic pulmonary fibrosis; Hepatitis C; Idiopathic pulmonary fibrosis / usual interstitial pneumonia; Interferon alpha

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