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Kidney Int. 2013 Apr;83(4):541-3. doi: 10.1038/ki.2012.434.

Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease.

Author information

1
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA. gorin@uthscsa.edu

Abstract

Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity.

PMID:
23538692
PMCID:
PMC3616333
DOI:
10.1038/ki.2012.434
[Indexed for MEDLINE]
Free PMC Article

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