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J Perinatol. 2013 Sep;33(9):717-20. doi: 10.1038/jp.2013.28. Epub 2013 Mar 28.

Refeeding syndrome in very-low-birth-weight intrauterine growth-restricted neonates.

Author information

1
Division of Neonatology, Department of Pediatrics, Medical University of South Carolina Children's Hospital, Charleston, SC 29425, USA. rossjr@musc.edu

Abstract

OBJECTIVE:

Determine the incidence of refeeding syndrome, defined by the presence of hypophosphatemia in very-low-birth-weight (VLBW) infants with intrauterine growth restriction (IUGR) compared with those without IUGR.

STUDY DESIGN:

In this retrospective cohort study, VLBW infants admitted over a 10-year period (271 IUGR and 1982 non-IUGR) were evaluated for specific electrolyte abnormalities in the first postnatal week.

RESULT:

IUGR infants were significantly more likely to have hypophosphatemia (41% vs 8.9%, relative risk (95% confidence interval: 7.25 (5.45, 9.65)) and severe hypophosphatemia (11.4% vs 1%, 12.06 (6.82, 21.33)) in the first postnatal week. The incidence of hypophosphatemia was significantly associated with the presence of maternal preeclampsia in all VLBW infants (odds ratio (OR): 2.58 (1.96, 3.40)) when controlling for birth weight and gestational age.

CONCLUSION:

Refeeding syndrome occurs in VLBW infants with IUGR and born to mothers with preeclampsia. Close monitoring of electrolytes, especially phosphorus, is warranted in this population.

PMID:
23538644
DOI:
10.1038/jp.2013.28
[Indexed for MEDLINE]

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