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Pediatr Infect Dis J. 2013 Sep;32(9):1017-9. doi: 10.1097/INF.0b013e318292bf8c.

Even in pneumococcal sepsis CD62L shedding on granulocytes proves to be a reliable functional test for the diagnosis of interleukin-1 receptor-associated kinase-4 deficiency.

Author information

1
From the *Division of Pediatric Infectious Diseases and Immunology and Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University of Würzburg, Würzburg, Germany; †Department of Pediatric Pneumology and Immunology, Charité Children's Hospital; ‡Division of Immunology, Labor Berlin; §Institute of Medical Immunology, Charité, Campus Virchow Klinikum; ¶Medical Department I, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; and ‖Institute for Clinical Transfusion Medicine and Immunogenetics, Ulm, German Red Cross Blood Service, Baden-Württemberg-Hessen, and Institute for Transfusion Medicine, University Hospital Ulm, Ulm, Germany.

Erratum in

  • Pediatr Infect Dis J. 2013 Nov;32(11):1302. Liefse, Johannes [corrected to Liese, Johannes].

Abstract

A 9-month-old infant presented with fatal pneumococcal sepsis and attenuated inflammation indices. Even in septic conditions, flow cytometry-based CD62L shedding test on granulocytes proved to be a fast and reliable diagnostic tool for the detection of a defect in the innate immunity. Confirmatory immunologic and genetic assays identified an autosomal-recessive interleukin-1 receptor-associated kinase-4 deficiency due to compound heterozygous mutations.

PMID:
23538514
DOI:
10.1097/INF.0b013e318292bf8c
[Indexed for MEDLINE]

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