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Curr Opin Neurobiol. 2013 Aug;23(4):713-20. doi: 10.1016/j.conb.2013.02.016. Epub 2013 Mar 25.

Deep brain stimulation for addiction: why the subthalamic nucleus should be favored.

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Institut de Neurosciences de la Timone, UMR7289 CNRS & Aix-Marseille Université, Campus Santé Timone, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.


Surgical treatment for psychiatric disorders has been revitalized for the past ten years after deep brain stimulation (DBS) had shown its efficacy for the treatment of neurological disorders such as Parkinson's disease. In the field of psychiatric disorders, DBS has been first used for obsessive compulsive disorder and treatment-resistant depression. Only recently it has been proposed for the treatment of addiction. Whatever the disease, the selected target is a constant question. In this review, we present theoretical, empirical and technical arguments in favor of targeting the subthalamic nucleus as the best candidate over other areas for DBS in the treatment of drug addiction.

[Indexed for MEDLINE]

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