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Dev Cell. 2013 Mar 25;24(6):565-7. doi: 10.1016/j.devcel.2013.03.009.

RNA in the loop.

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Howard Hughes Medical Institute.


Long noncoding RNAs (lncRNAs) have been implicated in a variety of biological roles, particularly as cis or trans gene expression regulators. Reporting recently in Nature, Lai et al. (2013) show that a class of gene-activating lncRNAs combines two gene regulation paradigms: enhancer-directed chromosomal looping and RNA-mediated protein effector recruitment.

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