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Clin Radiol. 2013 Jul;68(7):716-20. doi: 10.1016/j.crad.2013.02.004. Epub 2013 Mar 26.

The role of colour Doppler sonography in the diagnosis of lower limb Klippel-Trénaunay syndrome.

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Shandong Medical Imaging Research Institute, Shandong Provincial Key Laboratory of Diagnosis and Treatment of Cardio-cerebral Vascular Diseases, Shandong University, Jinan, Shandong, China.



To investigate the accuracy of colour Doppler sonography as compared to phlebography in patients with Klippel-Trénaunay syndrome (KTS).


From September 2004 to May 2012, 59 consecutive patients seen in Shandong medical imaging research institute with a clinical suggestion of KTS were included. Thirty-four were female and 25 were male, with a mean age of 28.4 years. Colour Doppler sonography was used to assess the lower limb veins. The main sonographic criteria for a positive diagnosis were visualization of the lateral vein or sciatic vein, capillary haemangioma, and abnormality of the deep veins. These data were compared with phlebography findings. The κ statistic was used to determine the level of agreement. The sensitivity, specificity, positive and negative predictive values, and accuracy of colour Doppler sonography as a diagnostic test were assessed.


Colour Doppler sonography findings were positive in 21 of 59 patients with a clinical suggestion of KTS. The diagnosis was confirmed using phlebography in 22 patients. There were two false-positive results and one false-negative result by colour Doppler sonography. The κ-value was 0.892. Sensitivity, specificity, positive and negative predictive values, and accuracy for colour Doppler sonography were 95.4, 94.6, 91.3, 97.2, and 94.9%, respectively.


Colour Doppler sonography is an accurate, reliable, and non-invasive investigation in the assessment of patients with suspected KTS.

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