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J Neurosci. 2013 Mar 27;33(13):5499-506. doi: 10.1523/JNEUROSCI.4068-12.2013.

Learning increases intrinsic excitability of hippocampal interneurons.

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  • 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

Abstract

Learning-related intrinsic excitability changes of pyramidal neurons via modulation of the postburst afterhyperpolarization (AHP) have been repeatedly demonstrated in multiple brain regions (especially the hippocampus), after a variety of learning tasks, and in multiple species. While exciting and important, the changes in pyramidal neurons are only a part of the neural circuitry involved in successful learning. For a more complete picture of the dynamic learning-related changes in the neural network, changes in inhibitory circuitry must also be systematically examined and characterized. Here we show in young adult rats and mice that learning the hippocampus-dependent trace eyeblink conditioning task induces enhanced inhibition onto CA1 pyramidal neurons mediated, in part, by an increase in intrinsic excitability of somatostatin-positive inhibitory neurons (SOMs). Furthermore, both CA1 pyramidal and SOM interneurons shared a common cellular mechanism (reduction in SK channel-mediated AHP) that led to the learning-induced increased intrinsic excitability.

PMID:
23536065
PMCID:
PMC3678545
DOI:
10.1523/JNEUROSCI.4068-12.2013
[PubMed - indexed for MEDLINE]
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