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Fish Shellfish Immunol. 2013 Jun;34(6):1463-9. doi: 10.1016/j.fsi.2013.03.354. Epub 2013 Mar 25.

Anti-viral activity of galectin-1 from flounder Paralichthys olivaceus.

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  • 1Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity, China.


Galectins are a family of Ca(2+)-independent soluble lectins characterized by their affinity to β-galactosides. Mammalian galectins have been shown to play a defense role against certain bacteria, fungi and viruses. However, the immunological functions of galectins in fish is poorly characterized. Here we demonstrated that the expression of galectin-1 gene from the flounder Paralichthys olivaceus was decreased in the initial 8 h after challenge with poly I:C, then increased markedly from 24 h onwards, and the recombinant galectin-1 was able to neutralize the lymphocystis disease virus (LCDV), inhibiting the formation of cytopathic effects. In addition, the recombinant galectin had a potential anti-inflammatory activity against infection by LCDV, and was able to restrain the overexpression of the anti-viral protein gene mx against virus infection. These results indicate that flounder galectin-1 has an anti-viral activity, capable of reducing LCDV pathogenicity.

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