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Bioorg Med Chem Lett. 2013 May 1;23(9):2718-20. doi: 10.1016/j.bmcl.2013.02.085. Epub 2013 Mar 1.

Enantiocomplementary access to carba-analogs of C-nucleoside derivatives by recombinant Baeyer-Villiger monooxygenases.

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1
Instituto de Química Rosario (IQUIR, CONICET-UNR) and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina.

Abstract

A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer-Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commercially available non-chiral starting material.

PMID:
23535329
DOI:
10.1016/j.bmcl.2013.02.085
[Indexed for MEDLINE]
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