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Case Rep Dermatol Med. 2013;2013:370361. doi: 10.1155/2013/370361. Epub 2013 Feb 25.

Perforating disseminated necrobiosis lipoidica diabeticorum.

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Department of Dermatology and Venereology, Medical University Sofia, Sofia, Bulgaria.


Perforating necrobiosis lipoidica is a very rare clinical variant which consists of degeneration and transepidermal elimination of the collagen with few cases reported in the literature. In two-thirds of the patients it associates with diabetes, with no relation with the glucose control. We present a 42-year-old female patient with a 7-year history of diabetes on insulin therapy, referred to our clinic with a 3-year history of multiple asymptomatic firm plaques disseminated on the upper and lower extremities. The clinical and histological findings proved the diagnosis of perforating necrobiosis lipoidica.

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