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Neural Plast. 2013;2013:258582. doi: 10.1155/2013/258582. Epub 2013 Feb 21.

Influence of inflammation on poststroke plasticity.

Author information

1
Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Polish Academy of Science, 3 Pasteur Street, 02-093 Warsaw, Poland. m.liguz@nencki.gov.pl

Abstract

Age-related brain injuries including stroke are a leading cause of morbidity and mental disability worldwide. Most patients who survive stroke experience some degree of recovery. The restoration of lost functions can be explained by neuronal plasticity, understood as brain ability to reorganize and remodel itself in response to changed environmental requirements. However, stroke triggers a cascade of events which may prevent the normal development of the plastic changes. One of them may be inflammatory response initiated immediately after stroke, which has been found to contribute to neuronal injury. Some recent evidence though has suggested that inflammatory reaction can be also neuroprotective. This paper attempts to discuss the influence of poststroke inflammatory response on brain plasticity and stroke outcome. We also describe the recent anti-inflammatory strategies that have been effective for recovery in experimental stroke.

PMID:
23533818
PMCID:
PMC3595668
DOI:
10.1155/2013/258582
[Indexed for MEDLINE]
Free PMC Article
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