Format

Send to

Choose Destination
Dig Dis Sci. 2013 May;58(5):1176-84. doi: 10.1007/s10620-013-2620-2. Epub 2013 Mar 27.

A gutsy task: generating intestinal tissue from human pluripotent stem cells.

Author information

1
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Abstract

Many significant advances in our understanding of intestine development, intestinal stem cell homeostasis and differentiation have been made in recent years. These advances include novel techniques to culture primary human and mouse intestinal epithelium in three-dimensional matrices, and de novo generation of human intestinal tissue from embryonic and induced pluripotent stem cells. This short review will focus on the directed differentiation of human pluripotent stem cells into intestinal tissue, highlight novel uses of this tissue, and compare and contrast this system to primary intestinal epithelial cultures.

PMID:
23532718
PMCID:
PMC3661082
DOI:
10.1007/s10620-013-2620-2
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center