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Cancer Causes Control. 2013 Jun;24(6):1167-74. doi: 10.1007/s10552-013-0196-y. Epub 2013 Mar 27.

Nutrient-based dietary patterns of head and neck squamous cell cancer: a factor analysis in Uruguay.

Author information

1
Epidemiology Group, Department of Pathology, School of Medicine, Avenida Brasil 3080 department 402, 11300, Montevideo, Uruguay.

Abstract

OBJECTIVE:

The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck.

METHODS:

We used a case-control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis.

RESULTS:

We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81-4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27-0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs.

CONCLUSION:

Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field.

PMID:
23532561
DOI:
10.1007/s10552-013-0196-y
[Indexed for MEDLINE]

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