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J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):422-7. doi: 10.1097/MPG.0b013e318276a6a7.

Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease.

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1
Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Piazzale Golgi 19, Pavia, Italy. rachele.ciccocioppo@unipv.it

Abstract

We report on 2 patients affected by both celiac disease (CD) and ╬▓-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.

PMID:
23531481
DOI:
10.1097/MPG.0b013e318276a6a7
[Indexed for MEDLINE]
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