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Nanomedicine (Lond). 2013 Nov;8(11):1763-76. doi: 10.2217/nnm.12.204. Epub 2013 Mar 27.

Poly(ε-caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells.

Author information

1
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.

Abstract

AIM:

To evaluate the efficacy of electrically conductive, biocompatible composite scaffolds in modulating the cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs).

MATERIALS & METHODS:

Electrospun scaffolds of poly(ε-caprolactone) with or without carbon nanotubes were developed to promote the in vitro cardiac differentiation of hMSCs.

RESULTS:

Results indicate that hMSC differentiation can be enhanced by either culturing in electrically conductive, carbon nanotube-containing composite scaffolds without electrical stimulation in the presence of 5-azacytidine, or extrinsic electrical stimulation in nonconductive poly(ε-caprolactone) scaffolds without carbon nanotube and azacytidine.

CONCLUSION:

This study suggests a first step towards improving hMSC cardiomyogenic differentiation for local delivery into the infarcted myocardium.

PMID:
23530764
PMCID:
PMC3809159
DOI:
10.2217/nnm.12.204
[Indexed for MEDLINE]
Free PMC Article

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