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Biomarkers. 2013 May;18(3):183-95. doi: 10.3109/1354750X.2013.777116. Epub 2013 Mar 27.

Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective.

Author information

1
British American Tobacco, Southampton, UK. frazer_lowe@bat.com

Abstract

Manufacturers have developed prototype cigarettes yielding reduced levels of some tobacco smoke toxicants, when tested using laboratory machine smoking under standardised conditions. For the scientific assessment of modified risk tobacco products, tests that offer objective, reproducible data, which can be obtained in a much shorter time than the requirements of conventional epidemiology are needed. In this review, we consider whether biomarkers of biological effect related to oxidative stress can be used in this role. Based on published data, urinary 8-oxo-7,8-dihydro-2-deoxyguanosine, thymidine glycol, F2-isoprostanes, serum dehydroascorbic acid to ascorbic acid ratio and carotenoid concentrations show promise, while 4-hydroxynonenal requires further qualification.

PMID:
23530763
PMCID:
PMC3667677
DOI:
10.3109/1354750X.2013.777116
[Indexed for MEDLINE]
Free PMC Article
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