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Methods Mol Biol. 2013;998:109-18. doi: 10.1007/978-1-62703-351-0_8.

Recording of ion channel activity in planar lipid bilayer experiments.

Author information

1
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL, USA.

Abstract

Planar lipid bilayer is an electrophysiological technique that enables study of functional activities of ion channels, porins, and other pore-forming molecular complexes. The main purpose of this method is to monitor ion channels' behavior at the single molecule level in the artificial membranes. Here, I describe the details of this technique that will underline formation of the lipid bilayers and incorporation and activation of the ion channel protein.

PMID:
23529424
PMCID:
PMC3644985
DOI:
10.1007/978-1-62703-351-0_8
[Indexed for MEDLINE]
Free PMC Article

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