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PLoS One. 2013;8(3):e58709. doi: 10.1371/journal.pone.0058709. Epub 2013 Mar 20.

Chemerin is an antimicrobial agent in human epidermis.

Author information

1
Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.

Erratum in

  • PLoS One. 2013;8(10). doi:10.1371/annotation/4dfd522c-f0fd-40db-aadc-44cbef367a40.

Abstract

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val(66)-Pro(85), which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.

PMID:
23527010
PMCID:
PMC3604073
DOI:
10.1371/journal.pone.0058709
[Indexed for MEDLINE]
Free PMC Article

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