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Adv Healthc Mater. 2013 Oct;2(10):1309-13. doi: 10.1002/adhm.201200364. Epub 2013 Mar 25.

Combination delivery of antigens and CpG by lanthanides-based core-shell nanoparticles for enhanced immune response and dual-mode imaging.

Author information

1
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.

Abstract

Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.

KEYWORDS:

CpG ODN; antigens; co-delivery; dual-mode imaging; immune

PMID:
23526798
DOI:
10.1002/adhm.201200364
[Indexed for MEDLINE]
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