Send to

Choose Destination
Open Orthop J. 2013;7:47-50. doi: 10.2174/1874325001307010047. Epub 2013 Feb 22.

Should We Use Preoperative Epoetin-α in the Mildly Anemic Patient Undergoing Simultaneous Total Knee Arthroplasty?

Author information

Department of Orthopedics, Kingsbrook Jewish Medical Center, Brooklyn, NY 11203, USA.


Simultaneous knee arthroplasty is associated with significant blood loss. To prevent transfusion, three preoperative doses of epoetin-α were offered to mildly anemic simultaneous knee arthroplasty patients. A retrospective review, using ICD-9 codes, identified twenty patients from 2007-2009. Epoetin-α increased hemoglobin levels preoperatively (12.6 to 13.9, p<0.01). Twenty patients who did not receive epoetin-α were matched to study patients. Study patients were transfused less (55% vs 95%, p=0.012) and had similar inpatient length of stay. The average blood loss without transfusion was 4.6g/dL. The mildly anemic patient is at high-risk for packed red cell transfusion during simultaneous knee arthroplasty. Three preoperative doses of epoetin-α in the mildly anemic patient decreased total transfusions; however, it did not affect inpatient length of stay.


Single stage bilateral total knee arthroplasty; anemia.; degenerative joint disease; epoetin-α; pain; simultaneous total knee arthroplasty; tranexamic acid

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center