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Oncoimmunology. 2013 Feb 1;2(2):e22946.

Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression.

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1
Program in Cellular and Molecular Medicine; Boston Children's Hospital; Boston, MA USA ; Department of Pediatrics; Harvard Medical School; Boston, MA USA.

Abstract

Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.

KEYWORDS:

Cancer; NETs; metastasis; neutrophils; thrombosis; tumor progression

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