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Case Rep Oncol. 2012 May;5(2):367-72. doi: 10.1159/000341158. Epub 2012 Jul 10.

Primary lung cancer complicated by malignant lymphoma in two cases of epstein-barr virus infection.

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Department of Internal Medicine and, Chuno Kosei Hospital, Seki, Japan.



Double cancer is defined as the co-existence of two pathologically distinct cancers. Double cancer consisting of a lung adenocarcinoma and a malignant lymphoma has seldom been reported in time synchronous cases or prior to cases of primary lung cancer, except in those after treatment for malignant lymphoma.


Case 1 was a 71-year-old woman who was treated at our hospital for chronic hepatitis C, nontuberculous mycobacteria infection, and bronchiectasis. She was diagnosed with a stage IV lung adenocarcinoma (cT1bN2M1b) with a synchronous complicating diffuse large B-cell-type lymphoma. Case 2 was a 62-year-old man who had undergone resection of a stage IB lung adenocarcinoma (pT2aN0M0). Thirty months after the surgery, a diffuse large B-cell-type lymphoma was discovered. In both cases, high antiviral capsid antigen IgG antibody titers were observed.


Epstein-Barr virus may be associated with the incidence of multiple cancers given the pathological evidence from our two double cancer cases.


Diffuse large B-cell-type lymphoma; Double cancer; Epstein-Barr virus infection; Lung adenocarcinoma

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