Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2013 Apr;13(4):257-69. doi: 10.1038/nri3403.

T cell receptor signalling networks: branched, diversified and bounded.

Author information

1
Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, UK.

Abstract

Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation. Acquisition of appropriate effector T cell function requires the participation of multiple signals from the T cell microenvironment. Trying to understand how these signals integrate to achieve specific functional outcomes while maintaining tolerance to self is a major challenge in lymphocyte biology. Several recent publications have provided important insights into how dysregulation of T cell signalling and the development of autoreactivity can result if the branching and integration of signalling pathways are perturbed. We discuss how these findings highlight the importance of spatial segregation of individual signalling components as a way of regulating T cell responsiveness and immune tolerance.

PMID:
23524462
DOI:
10.1038/nri3403
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center