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J Am Coll Cardiol. 2013 Aug 20;62(8):677-84. doi: 10.1016/j.jacc.2013.01.080. Epub 2013 Mar 21.

Cardiometabolic consequences of gestational dysglycemia.

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1
Mount Sinai Hospital Department of Medicine, University of Toronto, Ontario, Canada.

Abstract

The development of gestational diabetes and even milder forms of dysglycemia during pregnancy represents a maternal phenotype at increased subsequent risk for developing type 2 diabetes mellitus, metabolic syndrome, and, with time, overt cardiovascular disease. A careful and systematic dissection of the hormonal, metabolic, and vascular changes occurring in such women during pregnancy and over the postpartum years provides a unique opportunity to identify conventional and novel conditions and biomarkers whose modification may attenuate adverse long-term outcomes, particularly cardiovascular risk. The purpose of this review is to summarize current understanding of the magnitude of such risk and its potential causes, with a particular focus on postpartum alterations in endothelial and vascular smooth muscle responsiveness.

KEYWORDS:

AUC(gluc); BMI; CI; CVD; EDD; EID; FMD; GCT; GDM; GIGT; HR; NGT; NO; OGTT; OR; T2DM; area under the glucose curve; body mass index; cardiovascular disease; cardiovascular risk; confidence interval; endothelial function; endothelium-dependent dilation; endothelium-independent dilation; flow-mediated dilation; gestational diabetes; gestational diabetes mellitus; gestational impaired glucose tolerance; glucose challenge test; hazard ratio; nitric oxide; normal glucose tolerance; odds ratio; oral glucose tolerance test; type 2 diabetes mellitus

PMID:
23524050
DOI:
10.1016/j.jacc.2013.01.080
[Indexed for MEDLINE]
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