Send to

Choose Destination
See comment in PubMed Commons below
Exp Gerontol. 2013 Oct;48(10):1075-84. doi: 10.1016/j.exger.2013.03.004. Epub 2013 Mar 21.

Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion.

Author information

McGill University Health Center, Department of Kinesiology, McGill University, Montreal, QC, Canada.


Caloric restriction (CR) has pronounced benefits in promoting healthy aging. Amongst the most frequently implicated physiological mechanisms implicated in this benefit is altered mitochondrial function. Whereas a reduction in mitochondrial reactive oxygen species (ROS) production is a widely consistent effect of CR, an increase in mitochondrial biogenesis, which is accepted by many as fact, is contradicted on several levels, most critically by a lack of increase in mitochondrial protein synthesis rate in vivo. Furthermore, an increase in PGC-1α protein and markers of mitochondrial content with CR is a highly variable observation between studies. On the other hand, deacetylation of several mitochondrial proteins by the sirtuin, Sirt3, is an increasingly reported observation and at least so far, this observation is consistent between studies. Notwithstanding this point, the controversies evident in the published literature underscore the significant questions that remain in our understanding of how CR impacts the mitochondrion and suggest we have yet to fully understand the complexities herein.


Aging; Caloric restriction; Mitochondria; PGC-1a; Sarcopenia; Sirtuin

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center