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Drug Discov Today. 2013 Sep;18(17-18):795-802. doi: 10.1016/j.drudis.2013.03.001. Epub 2013 Mar 21.

A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century.

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Discovery Chemistry & Research Technologies, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46158, USA.


This article describes our experiences in creating a fully integrated, globally accessible, automated chemical synthesis laboratory. The goal of the project was to establish a fully integrated automated synthesis solution that was initially focused on minimizing the burden of repetitive, routine, rules-based operations that characterize more established chemistry workflows. The architecture was crafted to allow for the expansion of synthetic capabilities while also providing for a flexible interface that permits the synthesis objective to be introduced and manipulated as needed under the judicious direction of a remote user in real-time. This innovative central synthesis suite is herein described along with some case studies to illustrate the impact such a system is having in expanding drug discovery capabilities.

[Indexed for MEDLINE]

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